More than 50 years of experience in the engineering and manufacturing of freeze dryers and over 1000 delivered installations and thousands of freeze drying tests carried out for the pharmaceutical and biotechnology industries underline GEA Lyophil’s technological leadership.


GEA Lyophil’s freeze dryer product line comprises laboratory freeze dryers, pilot plants for R&D purposes or small production batches, industrial size production freeze dryers as well as complete freeze dryer systems consisting of one or multiple freeze dryers plus ALUS® (Automatic Loading and Unloading System) and isolators.

Proven modules built together offer the possibility of choosing either a cost effective or a highly customized system. Each module and system component must meet the strictest requirements and regulatory standards around the world.

The design and manufacture of freeze dryers and freeze drying systems is carried out in accordance with all cGMP, CE, GAMP and 21 CFR Part 11 guidelines.

Lyovac® Freeze Dryers - Production Plants (Industrial freeze dryers)

Large scale production plants built to customer specifications

 

Shelf Size 8 - 58 m2

 

GEA Lyophil production Freeze Dryers are either non sterilisable units or steam respectively VHP sterilisable units.

 

 

Lyophilization Production Systems

Automation and highest contamination prevention.

The handling of pharmaceutical substances such as cytostatics creates a high need for operator and product protection.  A typical Freeze Dryer Production System incorporates the following components:

Pilot Plants

For R & D and Small Scale Production

Shelf Size 0.4 - 8 m2

 

Lab Units

For Laboratories, Universities and Research Institutes

Shelf Size 0.1 - 0.3 m2

 

Features of the freeze dryers include:

  • Choice of configurations, e.g. monoblock, 2-floor configurations
  • Various door configurations, including re-cooling, slot doors and many more
  • Reciprocating and screw compressors systems as well as LN2 cooling systems
  • Automatic CIP (Clean-in-Place) and SIP (Sterilisation-in Place) systems offer product protection, prevent contamination and increase the productivity by allowing a reduction in the number of staff needed to operate the equipment
  • AutomaticWIT (Water Intrusion Test) of the venting filters ensures integrity and increases the availability of the unit
  • Monitored stainless steel stoppering bellow
  • Proven vacuum pump system technology
  • VHP Technology: a cost saving and environmentally friendly alternative to steam sterilisation
  • SCADA system for controlling and monitoring of reproducible and documented processes, meeting 21 CFR Part 11 regulation

More information about Freeze Dryers (Lyophilizers):

 

Sterilization of Freeze Dryers  |  Retrofit  |  Loading/Unloading of Freeze Dryers  |  ALUS® 

 

Lyophilization Application Testing |  More about GEA Lyophil  |  Contact details of GEA Lyophil 

 

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Gefriertrockner und Automatische Beladesysteme  |  Automatische Be- und Entladesysteme

Gefriertrockner und Automatische Beladesysteme für die Pharma- und Biotechindustrie

Mehr als 50 Jahre Erfahrung im Design und der Herstellung von Gefriertrocknern für die Pharma – und Biotechindustrie beweisen GEA Lyophils technologische Führerschaft. GEA Lyophil liefert Laborgefriertrockner, Pilotgefriertrockner für die Entwicklung und kleine Produktionsmengen, Produktionsgefriertrockner im Industriemaßstab sowie vollständige Produktionssysteme mit einem oder mehreren Gefriertrocknern, automatischem Be- und Entladesystem (ALUS®) sowie Isolatoren ... weiter lesen

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