Product Know-How - Pharmaceutical processing expertise
Whether the customer's requirement is for mixing, granulation or drying, GEA Pharma Systems has a solution for every processing challenge. The Collette™ Single Pot (or One Pot) technology offers a choice of mixing, granulation and drying options integrated into one processing vessel. With our help, this allows the customer to choose the most appropriate technique for the product.
Key Characteristics
Flexible Processing
Single-Pot processing is an extremely flexible technology. Whether for standard wet granulation, melt granulation, pelletizing or effervescent production, combined with vacuum or microwave drying, a Single Pot processor can achieve the required result. The swinging bowl option enhances this flexibility even further by its capability to process older formulations to a high quality standard. Quick product changeover is achievable with easy and efficient cleaning, using a CIP system.
Compact and Cost-Effective Processing
Overall investment cost for a technology including installation cost and required cGMP space is becoming more and more important in the pharmaceutical industry. cGMP production area is expensive and is minimised wherever possible. Single Pot technology is a very compact technology achieved by incorporating several processing steps into one machine. This reduces the capital cost of the equipment and, by reducing the cGMP & technical space required for granule production, the overall project cost.
Contained Processing
Because of its very nature, a Single Pot process is contained. No transfers are required between process steps, except for loading the raw materials and unloading the dry granules. This is not only beneficial for protecting the operators from potent products, but also for protecting the products from external influences such as heat, light or moisture. Specific solutions are available for product loading and discharging to achieve the desired level of containment for the whole process.
Single Pot processing expertise
With the high-shear granulation technology as the basis, Single Pot processing relies on the application of a vacuum within the bowl to dry the wet mass. This technique allows drying of pharmaceutical compounds at low temperature, and for minimal environmental exhaust through very efficient solvent recovery, even if organic solvents are used for granulation.
The vacuum drying process can be enhanced by the Transflo™ technique or microwave drying ... learn more