Granulation & Drying Processes
Built-in process versatility
GEA Pharma Systems is in the unique position to have in-house experience with all commonly used wet granulation methods. Therefore, at the GPS Technology Centre you can test your material in a fluid bed spray granulator, top or bottom drive high shear granulator with fluid bed drying, with all tests being made in development, pilot scale plant or small scale production, depending on your needs.
At the GPS Technology Centre we can handle product volumes: 20 g to 100 kg
High Shear Granulation (utilising both 'top' and 'bottom' drive granulators)
High Shear Granulation can be single process OR automated drying with integrated fluid bed dryer.
| Available Plant |
Drive |
Scale |
Average Batch Size |
Fluid bed integration for Drying* |
| UltimaGral™ 75 |
Top |
Development / Pilot |
20 kg |
Size 2 fluid bed |
| UltimaGral™ 300 |
Top |
Pilot / Small Scale Production |
100 kg |
Size 4/5 fluid bed |
| PMA™ 65 |
Bottom |
Development / Pilot |
20 kg |
Size 2 fluid bed |
| PMA™ 300 |
Bottom |
Pilot / Small Scale Production |
100 kg |
Size 4/5 fluid bed |
High Shear Granulation processes supported at the GPS Technology Centre:
Wet Granulating
The high-shear granulation process combines the active powder and the excipients with a binder solution using a high-speed mixing blade and chopper.
Special features:
- Control of granulation process via in-line focus beam reflection measurement
Melt Granulating
Melt agglomeration is a process by which agglomeration - or size enlargement by which fine particles are bound together to agglomerates or granulates - is obtained through the addition of either a molten binder liquid or a solid binder which melts during the process. Agglomerates are formed by agitation of the mixture. To obtain a stable, dry granule, a cooling to ambient temperature is necessary to solidify the binder.
Process Integration
Current Good Manufacturing Practices increasingly require that product is fully contained during processing to protect operators and environment. Integrated process systems not only offer containment but improved productivity through automation, increased yield and efficient cleaning procedures.
At the GPS Technology Centre we are uniquely qualified to demonstrate state-of-the-art integrated High Shear Mixer Granulator and Fluid Bed Drying. Drawing on the world class expertise of GEA Pharma Systems companies, you are able to utilize our fully integrated turnkey installations including fluid bed process equipment combined with Top- and Bottom-drive High Shear Mixer-Granulators from Aeromatic-Fielder™ and Collette™.
Contact:
GEA Pharma Systems AG
GPS Technology Centre
PO Box 112, Hauptstrasse 145
CH-4416, Bubendorf, Switzerland
Tel: +41 61 936 37 00 Fax: +41 61 936 37 30
tc@geapharmasystems.com