Granulation & Drying Processes
Built-in process versatility
GEA Pharma Systems is in
the unique position to have in-house experience with all commonly used wet
granulation methods. Therefore, at the GPS Technology Centre you can test your
material in a fluid bed spray granulator, top or bottom drive high shear
granulator with fluid bed drying, with all tests being made in development,
pilot scale plant or small scale production, depending on your needs.
At the GPS Technology Centre we can handle product volumes: 20 g to
100 kg
High Shear Granulation (utilising both 'top' and 'bottom' drive
granulators)
High Shear Granulation can be single process OR automated drying with
integrated fluid bed dryer.
| Available Plant |
Drive |
Scale |
Average Batch Size |
Fluid bed integration for Drying* |
| UltimaGral™ 75 |
Top |
Development / Pilot |
20 kg |
Size 2 fluid bed |
| UltimaGral™ 300 |
Top |
Pilot / Small Scale Production |
100 kg |
Size 4/5 fluid bed |
| PMA™ 65 |
Bottom |
Development / Pilot |
20 kg |
Size 2 fluid bed |
| PMA™ 300 |
Bottom |
Pilot / Small Scale Production |
100 kg |
Size 4/5 fluid bed |
High Shear Granulation processes supported at the GPS
Technology Centre:
Wet Granulating
The high-shear granulation process combines the active powder and the
excipients with a binder solution using a high-speed mixing blade and chopper.
Special features:
- Control of granulation process via in-line focus beam reflection
measurement
Melt Granulating
Melt agglomeration is a
process by which agglomeration - or size enlargement by which fine particles
are bound together to agglomerates or granulates - is obtained through the
addition of either a molten binder liquid or a solid binder which melts during
the process. Agglomerates are formed by agitation of the mixture. To obtain a
stable, dry granule, a cooling to ambient temperature is necessary to solidify
the binder.
Process Integration
Current Good Manufacturing Practices increasingly require that product is
fully contained during processing to protect operators and environment.
Integrated process systems not only offer containment but improved productivity
through automation, increased yield and efficient cleaning procedures.
At the GPS Technology Centre we are uniquely qualified
to demonstrate state-of-the-art integrated High Shear Mixer Granulator and
Fluid Bed Drying. Drawing on the world class expertise of GEA Pharma
Systems companies, you are able to utilize our fully integrated turnkey
installations including fluid bed process equipment combined with Top- and
Bottom-drive High Shear Mixer-Granulators from Aeromatic-Fielder™ and Collette™.
Contact:
GEA Pharma Systems AG
GPS Technology
Centre
PO Box 112, Hauptstrasse 145
CH-4416, Bubendorf,
Switzerland
Tel: +41 61 936 37 00 Fax: +41 61 936 37 30
tc@geapharmasystems.com