Whether the customer’s requirement is for mixing or granulation, Collette has a solution for every processing challenge. With both low shear planetary mixers and high shear granulators in the range, Collette™ can help select the technology that is most suitable for the product and process.
GEA Pharma Systems nv, Collette™ has supplied mixer and granulator systems to various industries for more than a century, and to the pharmaceutical industry in particular for more than 50 years. Based on this experience, Collette™ supplies advanced solids processing systems for mixing, granulating and drying in the pharmaceutical industry. This includes small capacity systems designed for R & D as well as industrial size plants for batch production of pharmaceutical compounds under cGMP conditions.
Product Know-How - Process Expertise
Collette's plant and process expertise is based on experience and R & D. With more than 1000 plants installed around the world and literally thousands of tests performed, it has established a solid base of expertise related to the needs of the pharmaceutical manufacturing industry.
Plant design:
- Through the wall design offers the best option in terms of cleanliness, maintenance and explosion protection.
- Moveable Head – The UltimaGral™ can be equipped with a ‘Movable Head’ to enhance flexibility. This feature allows operators to lower the closed bowl to enable better accessibility and easy loading.
- Binder solution addition - In a wet granulation process, binder addition is one of the critical phases determining product quality. A range of binder addition systems is available to give the optimum binder liquid droplet size.
Process Control & Monitoring:
- A range of control systems for maximum level of flexibility and functionality for process visualisation, automation and data recording
- PAT Integration – Combining process monitoring using online analysers, together with solid process engineering principles and advanced process modelling techniques will enable processes to be actively controlled in order to compensate for minor input variations (eg. raw materials) so that the specifications for the final product will be closer to the ideal target.
Cleanability & Maintenance:
- Concealed services
- CIP and WIP
Containment:
- Complete contained processing
- For loading and unloading Buck® high containment split-valve technology
- For toxic compounds, isolator boxes can be integrated
- Product sampling
Continuous Improvement for Safety:
- EC type approved for pressure shock resistant integrated systems and 16-bar pressure shock resistant high shear granulators
From R & D to large scale production
Collette™ is the perfect partner for the development of a granulation process from formulation up to full-scale production. In R & D, the MicroGral™ is the ideal equipment for the customer's formulation studies on granulation and pelletization processes. It is suitable for batches from 100g to 700g by the availability of 2 interchangeable glass bowls of 1 l and 4 l. This table-top unit is equipped with an excellent process control system, including torque and temperature
measurement, as well as a data logging system with the ability to export data. With capacities from 10 l to 1200 l, the UltimaGral™ range can cover all requirements after the formulation stage. From clinical batch production for scale-up trials to large scale production for marketed products.
Collette UltimaGral™ product range:
- Development: MicroGral™, batches 100-700g & UltimaGral™ 10/25, batches 1-9kg
- Pilot Scale: UltimaGral™ 75/150, batches 10-50kg
- Production Scale: UltimaGral™ 300 to 1500, batches 50-550kg
Integration for optimum process efficiency
Our complete range of process equipment is designed with system integration in mind. A modular approach allows customers to select standard process modules to suit project needs. Fluid bed dryers and coaters can be combined with topdrive and bottom-drive high shear mixer-granulators, wet and dry milling facilities, product handling systems, binder and
coating preparation units, filtration units, all designed for fully integrated systems. Safety, containment, product flow and building requirements are in-built for full integration for optimum process efficiency.