Single Pot Processors
Single Pot
Processing with Collette UltimaPro
Single Pot processing offers
a choice of mixing, granulation and drying options integrated into one
processing vessel. With Collette's help, this allows the customer to choose the
most appropriate technique for the product. Using proven standard components,
Collette™ can supply both simplicity and flexibility in plant design.
User-selected process options, control systems and liquid recovery units
combine in a system to meet process requirements exactly. This approach ensures
that qualification and validation work can be kept to a minimum and secures
successful results ... Read more
and download
Technical article: Melt Granulation with
polyethylene glycol in a Single Pot Processor
This study
compares different processing methods to prepare a melt granulation with
polyethylene glycol (PEG) in a high shear mixer / single pot processor. For
melting the PEG, either the heated jacket or heated jacket supplemented with
microwaves was used to supply the necessary energy. For cooling the mass after
granulation, 3 methods were compared: cooling with the jacket, cooling with
pressurized air and cooling with liquid nitrogen ...
Read more and download
Technical article: Single Pot Systems for Drying Pharmaceutical
Granules
The first single pot units were mixer/granulators
retrofitted for vacuum drying. The energy needed for drying was provided by
heated jacket water. However, the single-pot system was only accepted by the
pharmaceutical industry when drying times were reduced dramatically by
microwave (1987) or by gas (1989) assistance. A number of different reasons
exist why single pot technology is selected for the production of granules:
- The yield of modern production-scale single-pot systems is far in excess of
99%.
- Organic solvents can be recovered relatively easily, as it is only
necessary to treat the pure solvent vapour rather than a large air flow with a
small organic solvent concentration as in the case of the fluidized bed
process. As the granules are dried in a vacuum atmosphere containing
practically no oxygen, the explosion risk is also reduced substantially.
- Where highly active substances are handled, the one-pot process allows a
relatively easy protection of the environment because of the fully contained
design and the integrated cleaning-in-place systems.
- One-pot units can be used for the aseptic production of granules since the
process is fully contained and an additional sterilizing-in-place system can be
installed ... Read more and
download