Single Pot Processing by Collette™

Collette™ plant and process expertise is based on experience and R&D. With more than 1000 plants installed around the world and literally thousands of tests performed, it has established a solid base of expertise related to the needs of the pharmaceutical manufacturing industry.

Whether the customer’s requirement is for mixing, granulation or drying, Collette™ has a solution for every processing challenge. Single Pot processing offers a choice of mixing, granulation and drying options integrated into one processing vessel. With Collette’s help, this allows the customer to choose the most appropriate technique for the product.

UltimaPro™ Single Pot Processor

Using proven standard components, Collette™ can supply both simplicity and flexibility in plant design. User-selected process options, control systems and liquid recovery units combine in a system to meet process requirements exactly. This approach ensures that qualification and validation work can be kept to a minimum and secures successful results.

Single Pot Processing - Compact, Flexible and Contained

Single Pot Technology, with its various processing options is ideal for many different applications and processing issues. Collette™, within GEA Pharma Systems, is able to assist in the selection of the most suitable and economical technology for its customers’ specific processing requirements.

Compact Technology
Overall investment cost for a certain technology including installation cost and required cGMP space is becoming more and more important in the pharmaceutical industry. cGMP production area is expensive and is minimised wherever possible. Single Pot technology is a very compact technology achieved by incorporating several processing steps into one machine. This reduces the capital cost of the equipment as well as the cGMP & technical space required for granule production and therefore the overall project cost.

Flexibility and Utilisation
Single Pot processing is an extremely flexible technology. Whether for standard wet granulation, melt granulation, pelletizing or effervescent production, combined with drying, a Single Pot Processor can achieve the required result. With easy and efficient cleaning, using a CIP system, quick product changeover is achievable.

Containment
Because of its very nature, a Single Pot process is a contained process. No transfers are required between process steps, except for loading the raw materials and unloading the dry granules. This is not only beneficial for protecting the operators from potent products, but also for protecting the products from external influences such as heat, light or moisture. Specific solutions are available for product loading and discharging to achieve the desired level of containment for the whole process.