The authors describe the in-line moisture measurement of a pharmaceutical
granulation of lactose, microcrystalline cellulose and crospovidone in a fluid
bed granulator dryer using top sprayed granulating liquid. A near-infrared
(NIR) prediction model was developed for moisture on spectra collected during a
calibration run. Subsequent granulations were analyzed for moisture content
real-time throughout the granulation and drying process using the NIR process
instrument.
Authors:
Robert A. Mattes is an instrumentation
scientist and Denise E. Root is marketing and process
instrument manager at FOSS NIRSystems, Inc. (Laurel, MD).
Andrew P.
Birkmire is a process engineer at GEA Pharma Systems, Inc.
(Columbia, MD).
Address correspondence to: rmattes@
foss-nirsystems.com.