GEA Pharma Systems - Collette™ has integrated its
granulation and drying process knowledge and experience to help operators
monitor and control the process easily. Depending on the automation and
reporting requirements, we can offer two different control systems both of
which provide the operator with all necessary process information in a clear
and easy to understand way.
Process Control
- OP/ PLC control system
This control system provides basic functionality and process
visualisation with data recording via a separate paperless recorder. It is FDA
21 CFR Part 11 compliant and provides a basic level of process automation with
recipe control.
- Procoll Pro control system
This SCADA based control system provides a maximum level
of flexibility and functionality in terms of process visualisation, automation
and data recording. It integrates with customer MES systems for receiving and
reporting GMP relevant data. The system is very much process orientated and
guides the creation of recipes using in-built intelligence and automatic
processing. All process data is stored in a
relational
database. The system is fully FDA 21 CFR Part 11 compliant and
provides features like audit trail including reporting and
configurable
graphs for process values. This batch control
system is designed according to
the S88.01 batch control
standards.
Process Monitoring
A video camera installed in the head of the machine provides a
complete view into the process vessel. This is the ideal tool for
state-of-the-art processing and gives the operator a clear indication of the
product behaviour and flow while the vessel is closed. Not only for product
development but also for production this feature provides a huge advantage for
modern integrated and contained processing.
Process Analytical Technology (
PAT) integration As well as the
classical tools for monitoring and controlling process like torque measurement
for granulation control, or temperature, pressure and energy input for the
drying process,
GEA Pharma Systems has developed innovative solutions
for the integration of PAT sensors (such as NIR, Raman, Focused Beam
Reflectance Measurement or FBRM) into its controls and processes. These
advanced measurement tools are used for the direct measurement of product
quality parameters such as moisture content, homogeneity of the mix, and
particle size distribution, providing control parameters for direct release of
the product.
GEA Pharma Systems has joined forces with J&M Analytik
AG to create a compact and cleanable in-process optical probe for use in powder
processing equipment. The result is the novel Lighthouse Probe™ (patent pending), which can
be used with a range of spectroscopic techniques, including NIR and UV/vis, to
overcome the traditional problem of product sticking to observation windows.