Using proven standard components, Collette™ (GEA Pharma Systems) can offer simplicity and flexibility in pharmaceutical plant design. User-selected process and drying options, control systems and liquid recovery units combine in a system to meet process requirements exactly. This approach ensures that qualification and validation work can be kept to a minimum and ensures successful results. Single Pot Processing builds upon the well established high shear granulation technology, all process options available for the UltimaGral™ range are also available for the UltimaPro™ range.
Through-the-wall configuration
Through-the-wall offers the best option in terms of cleanliness, maintenance and explosion protection. The Through-the wall configuration provides a sealed separation between technical and GMP space by the machine itself. This offers a clear containment concept including
explosion area separation that fulfils the latest requirements such as ATEX. By keeping technical components out of the process room, the equipment is much easier to clean. Maintenance is carried out from the technical area, reducing the need for the maintenance engineer to work in a GMP area. This reduces downtime and the risk of contamination. For ATEX, the design allows the technical area to be classified as safe.
Loading
Depending on the layout of the production area, several options for loading the powders are available. If the processing room is sufficiently high, gravity loading is possible using post hoists to lift the IBC on top of the UltimaPro™. Alternatively gravity loading with the IBC located on a docking station on the floor above the machine is possible in multiple floor installations. In height-restricted areas vacuum loading can be used with the product being sucked into the processing vessel from an IBC located close to the machine on the floor.
Moveable Head
The UltimaPro™ can be equipped with a ‘Movable Head’ to enhance flexibility. This feature allows operators to lower the closed bowl to enable better accessibility and easy loading. The closed bowl can also be raised for dust free discharging. This option is extremely useful in height-constrained processing areas
Binder solution addition
A range of binder addition systems is available to give the optimum binder liquid droplet size for an even distribution throughout the powder mass, for different viscosities. The liquid is transferred to the mixing bowl using a peristaltic pump or pressure vessel, while the rate and amount is controlled by a loss in weight system or a mass flow meter.