Production of dry sterile dosage forms often involves large-scale mixing of
the Active Pharmaceutical Ingredients (API) with one or more excipients. To
achieve a homogeneous mixture, the particle size distribution of the
excipient(s) must match that of the API. In a one-step operation, spray drying
can turn a sterile solution of the excipient into sterile particles of the
required size with no risk of introducing impurities – a well-known problem if
milling is used. Spray dryers for sterile production are completely
"tailor-made" for the task.