Product Know-How - Pharmaceutical processing expertise
Whether the customer's requirement is for mixing, granulation or drying, GEA
Pharma Systems has a solution for every processing challenge. The Collette™
Single Pot (or One Pot) technology offers a choice of mixing, granulation and
drying options integrated into one processing vessel. With our help, this
allows the customer to choose the most appropriate technique for the product.
Key Characteristics
Flexible Processing
Single-Pot processing is an
extremely flexible technology. Whether for standard wet granulation, melt
granulation, pelletizing or effervescent production, combined with vacuum or
microwave drying, a Single Pot processor can achieve the required result.
The swinging bowl option enhances this flexibility even further by its
capability to process older formulations to a high quality standard. Quick
product changeover is achievable with easy and efficient cleaning, using a CIP
system.
Compact and Cost-Effective Processing
Overall
investment cost for a technology including installation cost and required cGMP
space is becoming more and more important in the pharmaceutical industry. cGMP
production area is expensive and is minimised wherever possible. Single Pot
technology is a very compact technology achieved by incorporating several
processing steps into one machine. This reduces the capital cost of the
equipment and, by reducing the cGMP & technical space required for granule
production, the overall project cost.
Contained Processing
Because of its very
nature, a Single Pot process is contained. No transfers are required
between process steps, except for loading the raw materials and unloading the
dry granules. This is not only beneficial for protecting the operators from
potent products, but also for protecting the products from external influences
such as heat, light or moisture. Specific solutions are available for product
loading and discharging to achieve the desired level of containment for the
whole process.
Single Pot processing expertise
With the high-shear granulation technology as the basis, Single Pot
processing relies on the application of a vacuum within the bowl to dry the wet
mass. This technique allows drying of pharmaceutical compounds at low
temperature, and for minimal environmental exhaust through very efficient
solvent recovery, even if organic solvents are used for granulation.
The vacuum drying process can be enhanced by the Transflo™ technique or
microwave drying ... learn more