Here you will find all Technical Articles that cover the technology: Spray
Drying
Pharmaceutical actives are mainly produced by biotechnology or chemical
methods, normally involving a drying step as one of the very last unit
operations. Here the focus of interest is mainly on the residual moisture or
solvent content and also in the prevention of thermal degradation. The physical
appearance of the material is not of great interest at that time because this
is mostly modified during secondary production.
In secondary production, the solid dosage form is manufactured by blending
the active with the necessary excipients. The next step is typically to form
granules from this mixture by the means of wet granulation. After this a drying
step is required. The reason for this granulation/drying operation is that
modern high-speed tablet presses require materials with excellent flow
properties in order to produce tablets with the required homogeneity and weight
consistency.