Here you will find all Technical Articles that cover the technology: Tablet Compression
This article explains the ingenious design principles of the MODUL™ P, which make it the most advanced rotary tablet press – both for research & development and commercial production.
This document describes the results of an extensive containment measurement carried out on a complete tabletting installation, including a Courtoy MODUL™ S machine with Wash-off-line Exchangeable Compression Module.
The reported results are for a particular equipment installation and a particular formulation with active compound. The results should be used as a reference only, in comparison with which the containment level for other formulations can be estimated.
The MODUL™ is based on the unique ECM concept (patented), whereby the isolated Exchangeable Compression Module is removed from the machine in a contained way in a matter of minutes.
The contaminated but fully contained ECM is then placed on a dedicated trolley and transferred to a separate washing area for OFF-LINE opening, cleaning and format change-over. As the machine itself does not require any cleaning after removal of the ECM, the MODUL™ tablet press can be changed over from one format to another in as short a time as 30 minutes when using two ECMs. This leads to a significant reduction in the total product change-over time of the tabletting line, resulting in an important increase in productivity.
This article describes and explains the ECM concept and the many advantages it has to offer. This highly innovative concept, which is at the heart of the MODUL™ technology, is revolutionizing the pharmaceutical manufacturing process worldwide.
The controls dilemma facing the pharmaceutical compression industry since its infancy has been resolved by GEA Pharma Systems Courtoy Engineers. Like all great solutions, the answer is amazingly simple: physically separate the two control loops to work on separate areas of the press. Weight is controlled at pre-compression and hardness is controlled at main compression. As a result, weight and hardness can be controlled simultaneously and continuously on a standard tablet press. Yes, it is possible!
The Dual Control system is available as an option on the MODUL™ tablet press range. It allows for independent monitoring and control of tablet weight and tablet hardness. Thanks to the Dual Control system, tablets can be manufactured under constant thickness or constant hardness, without any influence on the superior weight control algorithm.
Several pharmaceutical companies are currently developing bi-layer tablets. For a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets.
This article explains why the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer-separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield, etc. Using a modified tablet press may therefore not be your best approach to producing a quality bi-layer tablet under GMP-conditions. Especially when in addition high production output is required.
The goal of tablet compression is to produce dosage forms that achieve the desired bioavailability and clinical effect. Traditional rotary tablet presses do not measure tablets’ tensile strength, yet this characteristic strongly influences tablet quality.The author describes a compression technique that accounts for tensile strength and produces tablets with consistent weight and disintegration time. This technique ensures tablets that are effective and readily used by the body ... Read more and download