Here you will find all Technical Articles that cover the technology: Tablet
Compression
The purpose of the collaboration between Sanico and GEA Courtoy was mainly
to investigate and qualify (and, whenever possible, to quantify) the advantages
of Courtoy’s innovative compression modes, in comparison with conventional
tablet presses ... Read more and download
When dealing with highly potent substances, compression is probably the most
challenging stage of the tablet manufacturing process ... Read more and download
This article explains the ingenious design principles of the MODUL™ P, which
make it the most advanced rotary tablet press – both for research &
development and commercial production.
This document describes the results of an extensive containment measurement
carried out on a complete tabletting installation, including a Courtoy MODUL™ S
machine with Wash-off-line Exchangeable Compression Module.
The
reported results are for a particular equipment installation and a particular
formulation with active compound. The results should be used as a reference
only, in comparison with which the containment level for other formulations can
be estimated.
The MODUL™ is based on the unique ECM concept (patented), whereby the
isolated Exchangeable Compression Module is removed from the machine in a
contained way in a matter of minutes.
The contaminated but fully contained ECM is then placed on a dedicated
trolley and transferred to a separate washing area for OFF-LINE opening,
cleaning and format change-over. As the machine itself does not require any
cleaning after removal of the ECM, the MODUL™ tablet press can be changed over
from one format to another in as short a time as 30 minutes when using two
ECMs. This leads to a significant reduction in the total product
change-over time of the tabletting line, resulting in an important increase in
productivity.
This article describes and explains the ECM concept and the many advantages
it has to offer. This highly innovative concept, which is at the heart of the
MODUL™ technology, is revolutionizing the pharmaceutical manufacturing process
worldwide.
The controls dilemma facing the pharmaceutical compression industry since
its infancy has been resolved by GEA Pharma Systems Courtoy Engineers. Like all
great solutions, the answer is amazingly simple: physically separate the two
control loops to work on separate areas of the press. Weight is controlled at
pre-compression and hardness is controlled at main compression. As a result,
weight and hardness can be controlled simultaneously and continuously on a
standard tablet press. Yes, it is possible!
The Dual Control system is available as an option on the MODUL™ tablet press
range. It allows for independent monitoring and control of tablet weight and
tablet hardness. Thanks to the Dual Control system, tablets can be manufactured
under constant thickness or constant hardness, without any influence on the
superior weight control algorithm.
Several pharmaceutical companies are currently developing bi-layer tablets.
For a variety of reasons: patent extension, therapeutic, marketing to name a
few. To reduce capital investment, quite often existing but modified tablet
presses are used to develop and produce such tablets.
This article explains why the development and production of quality
bi-layer tablets needs to be carried out on purpose-built tablet presses to
overcome common bi-layer problems, such as layer-separation, insufficient
hardness, inaccurate individual layer weight control, cross-contamination
between the layers, reduced yield, etc. Using a modified tablet press may
therefore not be your best approach to producing a quality bi-layer tablet
under GMP-conditions. Especially when in addition high production output is
required.
The goal of tablet compression is to produce dosage forms that achieve the
desired bioavailability and clinical effect. Traditional rotary tablet presses
do not measure tablets’ tensile strength, yet this characteristic strongly
influences tablet quality.The author describes a compression technique that
accounts for tensile strength and produces tablets with consistent weight and
disintegration time. This technique ensures tablets that are effective and
readily used by the body ... Read more and download