Whether your requirement is for mixing, granulation or drying, at GEA
Pharma Systems we have a solution for every processing challenge.
Collette™ UltimaPro™ Single Pot Processors (One-Pot
Processor) offer a choice of mixing, granulation and drying options
integrated into one processing vessel. With our help, choose the most
appropriate technique for the product.
UltimaPro™ Single-Pot Processor options:
Mixer - Granulator
With the high-shear granulation technology as the basis, Single Pot
Processing relies on the application of a vacuum within the bowl to dry the wet
mass. This technique allows drying of
pharmaceutical compounds at low
temperature, and for minimal environmental exhaust through very efficient
solvent recovery, even if organic solvents are used for granulation.
Vacuum Dryer - Gas-assisted Vacuum Dryer
The vacuum drying process can be enhanced by the addition of a small amount
of gas, passing through the product during the drying phase. The gas-assisted
vacuum drying (TransFlo™) technique results in shorter drying times and lower
residual moisture content of the final product.
Microwave Dryer
Microwaves can be added as an additional energy source to further enhance
the drying process . Because of the additional energy added to the process,
microwave drying is the fastest drying technique available in Single Pot
Processing. Through careful control of product temperature and forwarded and
reflected microwave power, this technique is ideal for the fast processing of
pharmaceutical products.
Key Characteristics:
- Flexible technology for standard wet granulation, melt granulation,
pelletizing or effervescent production, combined with vacuum or microwave
drying
- Swinging bowl options during vacuum drying results in an improvement of the
granule characteristics and a reduction in drying time
- Easy and efficient cleaning (CIP)
- Compact technology – reduce space requirement by incorporating several
processing steps into one machine
Process Control &
Monitoring:
- A range of control systems for maximum flexibility and functionality for
process visualisation, automation and data recording
- Process Analytical Technology (PAT) Integration – By combining process
monitoring using online analysers, with solid process engineering principles
and advanced process modelling techniques we enable processes to be actively
controlled to compensate for minor input variations (eg. raw materials) so that
the specifications for the final product will be closer to the ideal target.
Containment:
- The Single Pot process is a totally contained process
- No transfer between process steps
- For loading and unloading Buck® high containment split-valve technology
- Product sampling
Applications
- Contained production of highly active of toxic products
- Effervescent production
- Wet granulation using organic solvents
- Multiple product facilities requiring fast change-over
- ‘special’ applications (e.g. melt granulation, crystallization onto
substrates)
From R&D to large scale production
Collette is your partner for your granulation process from process
development up to full-scale production. With capacities from 10 litres to 1500
litres, the UltimaPro™ range can cover all requirements starting with the
process development stage and clinical batch production to scale-up trials and
large-scale production for marketed products.
Collette UltimaPro™ product range: